NH4Cl-HCO3--mediated hemolytic reaction in the erythrocytes of hereditary spherocytosis.
نویسندگان
چکیده
منابع مشابه
The Phosphorylated Carbohydrate Intermediates from Erythrocytes in Hereditary Spherocytosis.
By A. WILLIAM SHAFER T HE BASIS for the abnormal morphology of the erythrocytes in hereditary spherocytosis ( HS ) has intrigued investigators for many years. Prankerd and Altman’ and Prankerd, Altman and Young2 reported that after a relatively long period of incubation ( 1-6 hours ) with p32 orthophosphate, the rate of laI)eliflg of adenosine triphosphate (ATP) and 2, 3-diphosphoglycerate ( DP...
متن کاملAbnormal phosphoenolpyruvate transport in erythrocytes of hereditary spherocytosis.
The rate of phosphoenolpyruvate transport in erythrocytes from patients with hereditary spherocytosis and from healthy individuals was examined in a 0.1 M citrate buffer (pH 6.1 at 37 degrees C) containing 10 mM phosphoenolpyruvate and 10 mM NaF. The rate in erythrocytes from patients with hereditary spherocytosis was 0.09 +/- 0.02 mumol/min/ml of cells (mean +/- SD, n = 8), whereas the rate in...
متن کاملHereditary spherocytosis.
Hereditary spherocytosis is a common inherited disorder that is characterised by anaemia, jaundice, and splenomegaly. It is reported worldwide and is the most common inherited anaemia in individuals of northern European ancestry. Clinical severity is variable with most patients having a well-compensated haemolytic anaemia. Some individuals are asymptomatic, whereas others have severe haemolytic...
متن کاملHereditary spherocytosis.
Hereditary spherocytosis is a congenital haemolytic anaemia due to defect in spectrin-a RBC membrane protein and is transmitted as autosomal dominant. Due to this defect there is presence of characteristic spherical cell in peripheral blood smear and osmotic fragility is increased. Haemolytic anaemia, reticulocytosis, jaundice and splenomegaly are present. This article reports a case of a 9 yea...
متن کاملHereditary Spherocytosis
A 12-year-old girl was brought to the Dhaka Hospital of ICDDR,B with diarrhoea. Incidentally, the parents provided a history of repeated episodes of pallor and jaundice since she was two and half years old. Three of her family members had similar problems. History, clinical examination, and laboratory findings of the girl and her family members suggested a case of hereditary spherocytosis. To o...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1986
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.148.119